Intrathecal baclofen for dystonia: Benefits and complications during six years of experience
Identifieur interne : 004A49 ( Main/Exploration ); précédent : 004A48; suivant : 004A50Intrathecal baclofen for dystonia: Benefits and complications during six years of experience
Auteurs : Ruth H. Walker [États-Unis] ; Fabio O. Danisi [États-Unis] ; David M. Swope [États-Unis] ; Robert R. Goodman [États-Unis] ; Isabelle M. Germano [États-Unis] ; Mitchell F. Brin [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adult, Agonist, Baclofen, Baclofen (administration & dosage), Baclofen (adverse effects), Chemotherapy, Dystonia, Dystonia (drug therapy), Female, Gabaergic agonist, Gabaergic receptor B, Human, Humans, Implanted, Infusion Pumps, Implantable, Injections, Spinal, Intrathecal administration, Intrathecal baclofen, Male, Middle Aged, Muscle Relaxants, Central (administration & dosage), Muscle Relaxants, Central (adverse effects), Muscle relaxant, Pump, Toxicity, Treatment, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Baclofen, Muscle Relaxants, Central.
- chemical , adverse effects : Baclofen, Muscle Relaxants, Central.
- drug therapy : Dystonia.
- Adult, Female, Humans, Infusion Pumps, Implantable, Injections, Spinal, Male, Middle Aged, Treatment Outcome.
Abstract
Fourteen patients with primary or secondary dystonia received intrathecal baclofen (ITB) through an implanted pump following a trial dose. Patients were selected for ITB trial if they had clinically unsatisfactory responses to oral antidystonic medications, including oral baclofen. Patients were rated using the Burke‐Fahn‐Marsden rating scale by a blinded rater after the dose of ITB was optimized. Five patients experienced improvement in symptoms as determined by a change in rating scale scores, although only two had a clear clinical benefit. Etiology of dystonia did not determine the efficacy of ITB therapy, as benefit or failure was seen in both primary and secondary dystonia.
Url:
DOI: 10.1002/1531-8257(200011)15:6<1242::AID-MDS1028>3.0.CO;2-Z
Affiliations:
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Le document en format XML
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Swope</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Loma Linda, Loma Linda, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Goodman, Robert R" sort="Goodman, Robert R" uniqKey="Goodman R" first="Robert R." last="Goodman">Robert R. Goodman</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Germano, Isabelle M" sort="Germano, Isabelle M" uniqKey="Germano I" first="Isabelle M." last="Germano">Isabelle M. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-11">2000-11</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1242">1242</biblScope><biblScope unit="page" to="1247">1247</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">718E45EFF9BFDF5970287F8E572F95DC393AEB83</idno><idno type="DOI">10.1002/1531-8257(200011)15:6<1242::AID-MDS1028>3.0.CO;2-Z</idno><idno type="ArticleID">MDS1028</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Agonist</term><term>Baclofen</term><term>Baclofen (administration & dosage)</term><term>Baclofen (adverse effects)</term><term>Chemotherapy</term><term>Dystonia</term><term>Dystonia (drug therapy)</term><term>Female</term><term>Gabaergic agonist</term><term>Gabaergic receptor B</term><term>Human</term><term>Humans</term><term>Implanted</term><term>Infusion Pumps, Implantable</term><term>Injections, Spinal</term><term>Intrathecal administration</term><term>Intrathecal baclofen</term><term>Male</term><term>Middle Aged</term><term>Muscle Relaxants, Central (administration & dosage)</term><term>Muscle Relaxants, Central (adverse effects)</term><term>Muscle relaxant</term><term>Pump</term><term>Toxicity</term><term>Treatment</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Baclofen</term><term>Muscle Relaxants, Central</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Baclofen</term><term>Muscle Relaxants, Central</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Infusion Pumps, Implantable</term><term>Injections, Spinal</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Agoniste</term><term>Baclofène</term><term>Chimiothérapie</term><term>Dystonie</term><term>Homme</term><term>Implanté</term><term>Myorésolutif</term><term>Pompe</term><term>Récepteur gabaergique B</term><term>Stimulant gabaergique</term><term>Toxicité</term><term>Traitement</term><term>Voie intrarachidienne</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Pompe</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fourteen patients with primary or secondary dystonia received intrathecal baclofen (ITB) through an implanted pump following a trial dose. Patients were selected for ITB trial if they had clinically unsatisfactory responses to oral antidystonic medications, including oral baclofen. Patients were rated using the Burke‐Fahn‐Marsden rating scale by a blinded rater after the dose of ITB was optimized. Five patients experienced improvement in symptoms as determined by a change in rating scale scores, although only two had a clear clinical benefit. Etiology of dystonia did not determine the efficacy of ITB therapy, as benefit or failure was seen in both primary and secondary dystonia.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Walker, Ruth H" sort="Walker, Ruth H" uniqKey="Walker R" first="Ruth H." last="Walker">Ruth H. Walker</name></region><name sortKey="Brin, Mitchell F" sort="Brin, Mitchell F" uniqKey="Brin M" first="Mitchell F." last="Brin">Mitchell F. Brin</name><name sortKey="Danisi, Fabio O" sort="Danisi, Fabio O" uniqKey="Danisi F" first="Fabio O." last="Danisi">Fabio O. Danisi</name><name sortKey="Germano, Isabelle M" sort="Germano, Isabelle M" uniqKey="Germano I" first="Isabelle M." last="Germano">Isabelle M. Germano</name><name sortKey="Goodman, Robert R" sort="Goodman, Robert R" uniqKey="Goodman R" first="Robert R." last="Goodman">Robert R. Goodman</name><name sortKey="Swope, David M" sort="Swope, David M" uniqKey="Swope D" first="David M." last="Swope">David M. Swope</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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